Flu Vaccination Proves to Reduce Rejection in Transplant Recipients

transplant_7-30-200x300Although we are currently in the throws of summer heat, schools will be starting back in the next few weeks and soon the Fall season will be upon us. With that begins flu season. The Emory Transplant Center has always encouraged our patients to get their flu shot early on in the season, and now a research study has proven it to be most effective in reducing rejection. A recent Emory study presented at the Emory Transplant Center shows that a flu shot in the first year post-transplant reduces rates of hospitalization for recipients of all organ types. The study also proved that vaccination reduces acute rejection rates among transplant recipients.

“We designed our study to compare the clinical outcomes between solid organ transplant recipients [lung, heart, kidney, and liver] at Emory University Hospital who receive flu vaccination with those who didn’t,” says Dr. G. Marshall Lyon III, Associate Professor of Medicine and Director of Transplant Infectious Diseases.

The investigators reviewed the charts of 586 recipients who received transplants from January 1, 2011 to September 1, 2012. They studied a cohort of patients who received flu vaccines during the first full flu season after their transplants and compared it to a cohort of non-vaccinated patients. The researchers collected the outcomes from each recipient for one year beginning with the start of the first full flu season – September 1st – after their transplants.

The study showed the recipients had an overall vaccination rate of 59.3%. The rate of hospitalization per patient year was lower in the vaccinated group, with 0.34 admissions per patient year for the vaccinated group and 0.51 admissions per patient year in the non-vaccinated group. When rejection episodes that were diagnosed on the date of vaccination were removed from the vaccinated group and attributed to the non-vaccinated group, there was a significant reduction in the rate per patient year, with a rejection rate of 0.13 for vaccinated patients and 0.22 non-vaccinated patients.

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