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HPV16 Vaccine Safe and Effective

Winship Cancer Institute of Emory University

Winship Cancer Institute of Emory University

Some cancers remain stubborn to treat. Pancreatic cancer, small cell lung cancer, late stage breast cancer and ovarian cancer are just a few of them. So when researchers find treatments – and even better, ways to prevent cancer – we celebrate.

Scientists at Winship Cancer Institute and many other research centers were therefore concerned about a recent statement that a vaccine to prevent cervical cancer causes mental illness. The statement is not accurate. The vaccine is safe. It is also effective. It is a great example of the medical advances that cancer researchers and clinicians can point to in the struggle against cancer.

The vaccine, which prevents the spread of Human Papilloma Virus-16 or HPV-16, has been approved by the FDA for use in girls who are not yet sexually active.  The vaccine is also under consideration for approval in boys to help prevent the spread of HPV16-related head and neck cancers caused by the same virus. Many researchers and clinicians consider HPV16-related head and neck cancers to be at epidemic levels.

“We don’t need to wait until all these molecular events are understood,” said Dong Moon Shin, M.D., director of Winship Cancer Institute’s head and neck cancer prevention program.  “This vaccine is successful in preventing cervical cancer, and we are hoping the vaccine provide similar preventive properties in head and neck cancer. We are very hopeful.”

Steve Jobs, Pancreatic Cancer & the Whipple Procedure

Dr. David Kooby, Emory10/6/2011 Update – A true visionary and leader in his field, we honor Steve Jobs (1955-2011) for his contributions and celebrate the tremendous impact he has had on the world. A reminder that we have a long way to go in the field of pancreatic cancer treatment. He will be deeply missed.

Most of you have probably heard the news that Steve Jobs has stepped down as Apple’s CEO. As he puts it, “I’ve always said if there ever came a day when I could no longer meet my duties and expectations as Apple’s CEO, I would be the first to let you know. Unfortunately, that day has come.” Jobs’ resignation comes not as a surprise to most. He was diagnosed with a rare type of pancreatic cancer in 2003 after doctors found his islet cell neuroendocrine tumor, a pancreatic cancer type that affects only about 2,000 of the 43,000 (~5%) people diagnosed with pancreatic cancer each year.

After receiving his pancreatic neuroendocrine cancer diagnosis, Jobs underwent surgery known as a pancreaticoduodenectomy (Whipple procedure) in 2004 to remove his cancer. The Whipple procedure involves removing a portion (the head) of the pancreas along with several surrounding organs, with the intent of rendering the patient cancer free. While it is a complex operation with substantial risk of complications and even death, for some patients with cancers of the pancreas like Jobs, it may provide the only hope for a cure.

The outcomes of the Whipple procedure are largely dependent on the unique circumstances of the patient, the tumor, and the expertise of the surgical team performing the procedure. What is known, however, is that survival rates from the Whipple procedure are higher at hospitals that specialize in this type of surgery. A recent study of the Whipple procedure reported in The New England Journal of Medicine found that operative mortality rates to be four times higher at low-volume hospitals (16%) than at high-volume hospitals (3.8%). Emory Healthcare is home to one of few of the Southeast’s high volume Whipple procedure programs, having performed 119 Whipple procedures in 2010 alone.

We know the risks and we know what it takes to reduce them. Emory has created a clinical pathway for Whipple procedure patients, making sure every step is taken to support quality outcomes and increase the hope for survival from cancer of the pancreas. A minimally invasive approach may be an option for selected patients who are in need of this operation.

Related Resources:

Pancreatic cancer Whipple procedure Sanjay GuptaYou can hear more about Steve Jobs, his pancreatic cancer diagnosis and treatment options in this CNN video interview with Dr. Sanjay Gupta and Dr. David Kooby of Emory.

 

 

Learn more about how Emory is improving outcomes for patients needing the Whipple procedure and more about the program, or check out the video below:

Learn more about pancreatic cancer and how it’s treated at the Winship Cancer Institute of Emory University.

Myths About Tobacco-Related (Bladder) Cancer Go Up in Smoke

Smoking Bladder Cancer RiskMany people think that cigarette smoking causes only lung cancer. If you are one of them, think again.

A study published just this week in the Journal of the American Medical Association (JAMA) finds that risk of developing bladder cancer – for men and women – is higher among smokers than previously believed.

Doctors such as Dr. Viraj Master, associate professor of urology, Emory School of Medicine and director of clinical urology research at the Winship Cancer Institute of Emory University, see patients every week whose cancers likely were caused by smoking.

“Patients are often surprised to hear of the link between smoking and bladder cancer, but it’s there and it’s real,” says Dr. Master. “Smoking’s effects on the body are both pervasive and lethal.”

How could it be that cigarette smoke gets into your bladder? As it turns out, the actual smoke does not, but the carcinogens in tobacco smoke do get into your blood stream and thus into other parts of your body. The study, authored by researchers at the National Cancer Institute, suggests that an apparent increase in the concentration of carcinogens has occurred in the past 50 years, even as tar and nicotine concentrations have been reduced.

Other cancers caused from smoking include: throat, mouth, nasal cavity, esophagus, stomach, pancreas, kidney, bladder, cervix, and acute myeloid leukemia. If you or a loved one would like help to quit smoking, you can call the Georgia Tobacco Quit Line at 877-270-STOP (7867).

Also, if you are a heavy smoker between 55 and 74, you may be interested in having a CT screening of your lungs. Emory University Hospital began offering such scans in early August. A study published this summer in the New England Journal of Medicine showed that low-dose spiral CT scans of heavy smokers aged 55 to 74 reduced mortality by 20 percent. People who are screened need to be aware that false positives may occur and that further testing may be required.

Lung Cancer Risk Reduction via Lung CT Scans Continue to Gain Momentum

Lung CT Screening

Did you know that only 15% of lung cancer patients survive more than 5 years after their cancer has been identified? As Vicki Griffin of the Atlanta Journal Constitution puts it in a recent AJC article on lung cancer, “The bleak bottom line is that lung cancer overwhelmingly terminates lives within months of the initial diagnosis.” But as Dr. Curran of the Winship Cancer Institute reported weeks ago in a lung cancer blog post, this number could be improved. How, you ask? Through low-dose Lung CT scanning.

A recent 5 year study sponsored by the National Cancer Institute (NCI), which is the same organization that has designated the Winship Cancer Institute as one of only 65 NCI designated cancer centers in the United States, shows that when lung adenocarcinomas are caught in earlier, more treatable stages, lung cancer death rates for those at high risk are reduced by 20%. Based on our knowledge that 157,000 people died at the hands of lung cancer in the U.S. in 2010 alone, this means last year, over 31,000 lives could have been saved.

The study evaluated over 53,000 participants at high risk for lung cancer in 25 states, including Georgia. As part of the evaluation of the effectiveness of low-dose Lung CT scans, the study compared the ability for Lung CT screenings and the currently standard chest X-ray technology to identify lung cancer early on.

Emory was a participant in the NCI sponsored study, and we conducted trials across the state of Georgia. As a result of the study’s significant findings, our teams at the Emory Clinic and Emory University Hospital Midtown are now offering current and former smokers with a significant smoking history high risk for lung cancer an opportunity to get a Lung CT scan at very reasonable rates.

Lung cancer remains the number one cancer killer in the U.S., claiming more lives than the next three most common cancer killers — prostate, breast and colorectal cancers – combined. But Lung CT screening may help with the early diagnosis and ultimately, increased survival rates, for lung cancer patients.

For more information on Lung CT scanning, or to find out if you are a candidate for screening, please visit our newly launched website dedicated to educating our community on Lung CT screening and its benefits. You can also call us for more information at 404-778-7777.